Novel Mechanism for Fluoroquinolone Resistance in Acinetobacter baumannii
نویسندگان
چکیده
منابع مشابه
Novel mechanism for fluoroquinolone resistance in Acinetobacter baumannii.
An EZ::TNTnp transposon insertion in an open reading frame of unknown function (ncr) in Acinetobacter baumannii resulted in an 8-fold increase in ciprofloxacin resistance (Cip(r)). Transposon insertions in an ncr mutant that reduced Cip(r) back to wild type mapped to three genes encoding subunits of the RecCBD exonuclease. The ncr mutation increased transcription of the recCBD ge...
متن کاملA fluoroquinolone-resistant Acinetobacter baumannii without the quinolone resistance-determining region mutations.
Recently another MITE-like structure, called the integron mobilization unit (IMU), has been described flanking a defective class 1 integron harbouring a carbapenem resistance gene, blaGES-5, in a clinical Enterobacter cloacae strain. Although the IMU sequence is not related to the MITE reported in our study, IMU-based mobilization of the integron could be demonstrated using a transposase provid...
متن کاملDefining resistance in Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains.
We read with great interest the recent publication of Tien and colleagues in which they describe the antimicrobial susceptibilities of a large number of Acinetobacter baumannii-Acinetobacter calcoaceticus strains isolated from a medical center in Taiwan (1). They suggested that antimicrobial susceptibility was negatively associated with virulent potential because more-susceptible strains were r...
متن کاملColistin-resistant Acinetobacter baumannii: beyond carbapenem resistance.
BACKGROUND With an increase in the use of colistin methansulfonate (CMS) to treat carbapenem-resistant Acinetobacter baumannii infections, colistin resistance is emerging. METHODS Patients with infection or colonization due to colistin-resistant A. baumannii were identified at a hospital system in Pennsylvania. Clinical data were collected from electronic medical records. Susceptibility testi...
متن کاملCharacterization, Prevalence and Antibiotic Resistance of Acinetobacter baumannii Infecting Foodstuff
Background: Acinetobacter baumannii is a highly virulent bacterium. It causes opportunistic and nosocomial infections and is a threat to healthcare settings. It has also developed multidrug resistance (MDR) capacity. The nosocomial bacteria and antibiotic resistance are primordial and a significant public health concern. These bacteria and their threat can be prevented by reducing infected food...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2012
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00739-12